Methyl 2-acetyl-1H-benzo[d]imidazole-6-carboxylate

Methyl 2-acetyl-1H-benzo[d]imidazole-6-carboxylate - Names and Identifiers

Name	Methyl 2-acetyl-1H-benzimidazole-5-carboxylate
Synonyms	Methyl 2-acetyl-1H-benzimidazole-6-carboxylate Methyl 2-acetyl-1H-benzimidazole-5-carboxylate Methyl 2-acetyl-1H-benzo[d]imidazole-6-carboxylate 1H-Benzimidazole-5-carboxylic acid, 2-acetyl-, methyl ester 1H-Benzimidazole-6-carboxylic acid, 2-acetyl-, methyl ester 1H-BenziMidazole-6-carboxylic acid, 2-acetyl-, Methyl ester
CAS	145126-56-3
InChI	InChI=1S/C11H10N2O3/c1-6(14)10-12-8-4-3-7(11(15)16-2)5-9(8)13-10/h3-5H,1-2H3,(H,12,13)

Methyl 2-acetyl-1H-benzo[d]imidazole-6-carboxylate - Physico-chemical Properties

Molecular Formula	C11H10N2O3
Molar Mass	218.21
Density	1.326±0.06 g/cm3(Predicted)
Boling Point	413.6±37.0 °C(Predicted)
pKa	9.61±0.10(Predicted)
Storage Condition	Room Temprature

Methyl 2-acetyl-1H-benzo[d]imidazole-6-carboxylate - Introduction

Methyl, also known as Methyl, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White to light yellow solid
-Molecular formula: C13H11N3O3
-Molecular Weight: 257.25
-Melting point: 155-157 ° C
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide

Use:
- Methyl L is often used as an intermediate in organic synthesis and can be used to synthesize other compounds or drugs.
-It plays an important role in the preparation of anticancer drugs, antiviral drugs and hormone drugs.

Method:
The synthesis of Methyl L is usually achieved by the oxidation reaction of benzimidazole. The specific steps include reducing benzimidazolone hydrate to benzimidazole with potassium hydroxide and tert-butyl alcohol, then reacting benzimidazole and acetic anhydride to form 2-acetylbenzimidazole through appropriate acylation reaction, and finally preparing methylisine through carboxylation reaction.

Safety Information:
- Methyl has low toxicity under normal operating conditions, but the following matters need to be carefully noted:
-avoid contact with skin, eyes and respiratory tract, such as accidental contact, should immediately rinse with plenty of water.
-Wear personal protective equipment such as goggles, gloves and masks during operation.
-Operate in a well-ventilated place to avoid inhaling gas or steam.
-Waste to be disposed of in accordance with local regulations.

Last Update：2024-04-09 02:00:42